In doing studies with Amish people for over 40 years in Pennsylvania, and then analyzing the data, the authors of this paper noticed that a rare form of dwarfism caused by a homozygous recessive mutation in a gene called Sonic Hedgehog (named by nerds who work on drosophila genetics, as they discovered this gene) is NEVER comorbid with bipolar disorder. Sonic Hedgehog is a gene involved in embryogenesis! So a mutation in it can affect many pathways downstream. But since people who have this form of dwarfism NEVER have bipolar d/o, it is thought that Sonic Hedgehog may be protective against bipolar d/o. Now to find out what does the Sonic Hedgehog gene do that is protective. Might take a while… But a very interesting article. And hopefully helpful to us sooner than later.
http://www.nature.com/mp/journal/vaop/ncurrent/abs/mp2014118a.html
Bipolar1Blog 
What an amazing-sounding study! You have a wonderful way of explaining these dense studies to the “everywoman”! I rely on your intellect to help me out! Thank you so much for sharing this information.
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You are welcome! :)) What’s amazing is that having this type of dwarfism protects you from getting bipolar d/o!!!
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Thank you so very much! Come back and read some more :-)))
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Reblogged this on Bipolar1Blog and commented:
This is pretty amazing! Just wanted to reblog it. Would I rather rather have this form of dwarfism so I could be protected from having bipolar disorder? I do believe I would!
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