Looking Inside the Brain to Distinguish Bipolar from Depression | Technology Networks
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Another way to distinguish bipolar disorder from depression. Using MRI’s to look at the amygdala as people were processing faces showing different emotions showed that there are differences in amygdala activity between people who have bipolar disorder and depression.

“In people with bipolar disorder, the left side of the amygdala is less active and less connected with other parts of the brain than in people with depression.”

It is important to get the right diagnosis as treatment for bipolar disorder and depression is different and it can be deleterious to treat people with bipolar disorder as if they have depression.