Rare form of dwarfism confers protection against bipolar affective disorder.


In doing studies with Amish people for over 40 years in Pennsylvania, and then analyzing the data, the authors of this paper noticed that a rare form of dwarfism caused by a homozygous recessive mutation in a gene called Sonic Hedgehog (named by nerds who work on drosophila genetics, as they discovered this gene) is NEVER comorbid with bipolar disorder. Sonic Hedgehog is a gene involved in embryogenesis! So a mutation in it can affect many pathways downstream. But since people who have this form of dwarfism NEVER have bipolar d/o, it is thought that Sonic Hedgehog may be protective against bipolar d/o. Now to find out what does the Sonic Hedgehog gene do that is protective. Might take a while… But a very interesting article. And hopefully helpful to us sooner than later.


7 thoughts on “Rare form of dwarfism confers protection against bipolar affective disorder.

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