Dear Governor of Texas,

So, there is no such thing as a mental illness! Well, is there such a thing as physical illness? Paralysis is a form of illness. You were paralyzed when a tree fell on you while running and broke your spine. So we have now established that there is such a thing as physical illness. You have one! So we have also established that the physical body can break down and get sick.

Now let us ask whether the brain is part of the physical body. Well is the brain a part of the physical body? Yes, it is. The physical body can get sick, the brain is part of the physical body, therefore the brain can get sick! What happens when the brain gets sick? Well, the brain can get cancer, as in tumors. It can produce hormonal imbalances, as in diseases of the pituitary gland. It can result in illnesses such as Parkinson’t disease, a physical illness of the brain tissue called substantia nigra which is responsible for producing dopamine, a neurotransmitter. Neurotransmitters are molecules through which neurons communicate with each other and through which neurons communicate with other cells of the body, like muscle cells. Neurotransmitters are also involved in the production of feelings, emotions, thoughts. When neurotransmitters (either levels or types) go awry, we have a chemical imbalance that then results in symptoms of mental illness. Ostensibly, too much dopamine can cause aggression and hallucinations, too little serotonin can cause depression and muscle aches. There is GABA, nitrous oxide, epinephrine/adrenaline and norepinephrine/noradrenaline. And an imbalance in any of these neurotransmitters (and in others not yet known) can cause not only physical symptoms, but emotional, mental, and thinking disorders/illnesses.

So there it is, the human body can get illnesses, the human brain is part of the human body, therefore it too can get sick. Some of the illnesses that the human brain gets are mental illnesses, diseases of the emotions, thoughts, and feeling, as the brain is the seat of these things.

Perhaps, if you had appointed someone who believed in science and evolution as the chair of your state board of education, instead of the laughable Barbara Cargill, you might well have learned this.

Dr. Patrick McKeon presents Bipolar Disorder

A wonderful video describing the mental, emotional, and physical symptoms of bipolar d/o.

He talks about slowing down in depression and speeding up in mania, or elation as he calls it.

Very informative, highly recommend watching it.

Thank you Christina Tacaclu for this video. Christina is the newest member of my Bipolar1Blog group on Facebook 🙂

Texas Governor Vetoes Mental Health Bill Because He Doesn’t Believe Mental Illness Is Real

Yes folks, this is real! This is not an Onion article! What to say about this? I am at my wit’s end. Mental illness is not real, according to Texas governor Gregg Abbot and he vetoed a Mental Health bill, “a bipartisan bill which would give more resources to medical professionals that help residents dealing with mental health problems. The bill in question was widely popular, supported by many large medical associations in the state and both political parties.” And to make this decision, he consulted Scientologists!

Even though I am an atheist, this makes me want to scream “Jesus, almighty Christ, god, what the hell is happening here?” How do people like this get to positions of power? How much damage do they do and how much damage like this can a civilized society absorb and still stay civilized???

And what about the people in Texas with mental illness who would have benefited from this bill? And what about treatment of people with mental illness, since apparently it doesn’t exist, how does one get treated for it?

The implications are vast and frightening, this amount of idiocy and stupidity is chillingly frightening!

http://www.greenvillegazette.com/texas-governor-vetoes-mental-health-bill-because-he-doesnt-believe-mental-illness-is-real/

A Conversation.

Aral 7

Had a long conversation with a friend, some things became crystal clear to me as a result of simply talking! That is the power of talk therapy as well! The reason my life got derailed in so many ways between 2003 and 2009, seven long years, became abundantly clear, it was (1) Stopping Lithium and starting Lamictal, and (2) Talking to an unprincipled woman who was, unbeknownst to me,  a sexologist, but treating me as a psychologist for bipolar d/o. These two things almost led to my marriage ending, and I almost lost my son. This was one of the most difficult times in my life and believe me I have had some whoppers! My mood being on the verge of mania for years upon years did nothing whatsoever for the health of my marriage and our family life. My most beloved son suffered because of the home environment and took refuge in destructive things. It almost broke up our family, we almost lost each other and the very worst thing to me, I almost lost my son. Do you know what I went through and how it makes me feel now to think about it? Hell and absolutely hellish! But, somehow, through strength, love and with the parts of our brain that were healthy, we survived this near calamity. I was there for my son when he needed me, my husband managed to hang in there for me, and I was put back on Lithium at the hospital, after being hospitalized the second time in my life for full blown mania as a result of having been taken off Lithium and put on Lamictal. (Lamictal puts people with bipolar 1 in a hypomanic phase eventually leading to mania 😦 )

So, obviously my illness was to blame for all the near catastrophes in the past, but so was medical mismanagement and downright malpractice on the part of the sexologist.

Is there a why? Why did these things have to happen to me and my family? Well, I can ask why till the cows come home and it won’t really help me. What will help me is to know what happened, acknowledge that bad things happened, that catastrophic things almost happened, learn from them and move on. And don’t forget the PTSD medications, haha, just kidding. But seriously, I’ll never, never come off Lithium, NEVER!

And yes I am strong to have coped with all this “insanity”, to have helped my son through very difficult times, to have managed to keep my marriage intact. I think all three of us deserve a medal for bravery and valor in life. I think a LOT of people with mental illnesses deserve this medal. Perhaps we should forge one and start pinning them on people’s chests!

Living in strength, love and with a positive mindset, I send everyone love and hugs.

What Makes a Shooter Do It?

I RETURNED to my office in Hartford late one afternoon to find a future mass murderer sitting in my chair.

The visitor, Matthew Beck, was not yet a killer. He was a mentally ill accountant from the Connecticut Lottery telling tales of corruption at his office. He had pulled up a seat — mine — at the newspaper where I worked for an interview with one of my colleagues, who expressed relief afterward that the intense Mr. Beck did not have a gun.

Mr. Beck, however, did have guns. And a few months later, he brought one to work and fatally shot four top lottery officials before killing himself. The mass shooting, in March 1998, was the second worst in Connecticut until three years ago, when Adam Lanza killed 20 children and six adults at Sandy Hook Elementary School in Newtown, where my wife had once applied for a job.

I thought of both of these incidents in recent weeks as horrific shootings shattered communities in Charleston, S.C., and Chattanooga, Tenn. On Thursday, there was yet another shooting, this one in a Lafayette, La., movie theater by a gunman with a history of mental instability who left a trail of angry Internet postings. A familiar, achingly unsatisfying search was underway for answers to an old question: What causes someone to take innocent lives? The usual suspects were lined up: mental illness, twisted ideologies, substance abuse, a culture awash in guns.

This vexing issue was what my fellow Times journalist Michael Luo and I spent a year examining following the Sandy Hook massacre. After reviewing more than 1,000 court cases and forensic reports, conducting countless interviews and producing seven stories, we were certain of one thing: It was far too easy for firearms to fall into the wrong hands.

But the motivations behind the actions of those hands often remain maddeningly opaque. How did Dylann Roof, a 21-year-old high school dropout who drank and did drugs, come to immerse himself in white supremacism and end up accused of gunning down nine African-Americans at a Charleston church? In Chattanooga, why did Mohammod Abdulazeez, 24, a college graduate struggling with depression and drug abuse, gravitate to radical Islam and fatally shoot five servicemen?

Mark Potok, who has spent decades researching hate groups and their followers for the Southern Poverty Law Center, said many shooters turned out to be “people who are looking for something larger than their own small lives, to be seen as a hero standing up for a cause.” Suspects like Mr. Roof go on the Internet and discover groups that validate their feelings and offer a sense of belonging, he said.

“It was once viewed as very unlikely that a person could be radicalized solely through a computer screen, but something has changed,” Mr. Potok said. “Today, the Internet really is the language of young people like Dylann Roof.”

As for Mr. Abdulazeez, he appears to have researched Islamic martyrdom on the web, although it was not clear he ever directly communicated with anyone espousing terrorism. The specter of self-radicalized “lone wolf” killers in the age of the Internet has added a frightening dimension to the 21st century variant of the mass shooter.

The widespread availability and glorification of firearms also cannot be overlooked as an important ingredient in this toxic mix, said Brad Bushman, a psychology professor at Ohio State University who served on a White House task force on gun violence after the Sandy Hook shooting. Numerous studies have shown that the mere presence of a weapon can make people more aggressive.

“I think guns are great equalizers, especially for people with limited voice, people on the fringes of society who may be rejected by peers or are trying to make themselves feel more accepted,” Mr. Bushman said. “Guns make people feel more powerful.”

For all their differences in motives and targets, mass shooters fall along a continuum of violence that is unnerving in its steady forward march. An F.B.I study found that between 2007 and 2013, there were an average of 16.4 such shootings a year, compared with 6.4 from 2000 to 2006. It is hard not to feel a growing sense of foreboding and futility, that we cannot escape their recurrence. Each new case delivers not just a blow to our collective conscience, but a there-but-for-the-grace-of-God moment.

One result of the Connecticut Lottery killings was a state law enabling the police to more easily seize firearms from people deemed to be a threat. The court records of these cases form a catalog of near misses and hint at the pervasiveness of firearms among all social strata.

There was the 24-year-old man found sitting in his car outside an ex-girlfriend’s place, crying and holding a gun on his lap. After disarming the man and getting him to a hospital, police officers entered his home and discovered seven high-powered rifles, a gas mask, knives and a backpack filled with 1,000 rounds of ammunition and survival gear.

A 27-year-old insurance company employee with bipolar disorder was found walking around with a gun in his pocket and six more stashed in his house, after a concerned relative reported that he was behaving strangely. Then there was the paranoid schizophrenic, 55, who had 18 guns taken away after he threatened to kill his mother and a nurse. When I interviewed him at his trailer near some railroad tracks in 2013, he told me how important his firearms were to him, showed me his empty gun safe and said he intended to refill it.

Indeed, one is struck by the nexus of mental instability, substance abuse and easy access to firearms. A regulatory loophole and bureaucratic bungling allowed Mr. Roof to buy a handgun despite a drug arrest that should have prevented it. Mr. Lanza, a deeply disturbed loner fascinated by mass killings, lived with his mother, who legally owned a small arsenal. And Mr. Beck was able to keep a pistol permit, even though he had been hospitalized twice for depression.

But, of course, most people with mental health problems are not violent, let alone prone to mass murder. What makes someone seek solace in a spasm of bloodshed is perhaps unknowable. That sense of mystery was captured in a letter released publicly by Mr. Beck’s parents after his killing rampage. In it, Donald and Priscilla Beck lamented that despite “the love and help from friends and family and the treatment, counseling and medications from his doctors, he chose the wrong path.”

“We love you Matt,” they wrote. “But why?”

Scientists identify schizophrenia’s ‘Rosetta Stone’ gene

DNA bases

DNA – sequence of bases. Credit: FreeImage.com / schulergd

Breakthrough reveals gene’s influence in a vulnerable period of the brain’s development

Scientists have identified a critical function of what they believe to be schizophrenia’s “Rosetta Stone” gene that could hold the key to decoding the function of all genes involved in the disease.

The breakthrough has revealed a vulnerable period in the early stages of the brain’s development that researchers hope can be targeted for future efforts in reversing schizophrenia.

In a paper published in the journal Science, neuroscientists from Cardiff University describe having uncovered the previously unknown influence of a gene in ensuring healthy brain development.

The gene is known as ‘disrupted in schizophrenia-1’ (DISC-1). Past studies have shown that when mutated, the gene is a high risk factor for mental illness including schizophrenia, major clinical depression and bipolar disorder.

The aim of this latest study was to determine whether DISC-1’s interactions with other proteins, early on in the brain’s development, had a bearing on the brain’s ability to adapt its structure and function (also known as ‘plasticity’) later on in adulthood.

Many genes responsible for the creation of synaptic proteins have previously shown to be strongly linked to schizophrenia and other brain disorders, but until now the reasons have not been understood.

The team, led by Professor Kevin Fox from Cardiff University’s School of Biosciences, found that in order for healthy development of the brain’s synapses to take place, the DISC-1 gene first needs to bind with two other molecules known as ‘Lis’ and ‘Nudel’.

Their experiments in mice revealed that by preventing DISC-1 from binding with these molecules – using a protein-releasing drug called Tamoxifen at an early stage of the brain’s development – it would lack plasticity once it grows to its adult state, preventing cells (cortical neurons) in the brain’s largest region from being able to form synapses.

The ability to form coherent thoughts and to properly perceive the world is damaged as a consequence of this.

Preventing DISC-1 from binding with ‘Lis’ and ‘Nudel’ molecules, when the brain was fully formed, showed no effect on its plasticity. However, the researchers were able to pinpoint a seven-day window early on in the brain’s development – one week after birth – where failure to bind had an irreversible effect on the brain’s plasticity later on in life.

“We believe that DISC-1 is schizophrenia’s Rosetta Stone gene and could hold the master key to help us unlock our understanding of the role played by all risk genes involved in the disease,” said Professor Fox.

“The potential of what we now know about this gene is immense. We have identified a critical period during brain development that directs us to test whether other schizophrenia risk genes affecting different regions of the brain create their malfunction during their own critical period.

“The challenge ahead lies in finding a way of treating people during this critical period or in finding ways of reversing the problem during adulthood by returning plasticity to the brain. This, we hope, could one day help to prevent the manifestation or recurrence of schizophrenia symptoms altogether.”

Professor Jeremy Hall, an academic mental health clinician and director of Cardiff University’s Neuroscience and Mental Health Research Institute, said:

“This paper provides strong experimental evidence that subtle changes early on in life can lead to much bigger effects in adulthood. This helps explain how early life events can increase the risk of adult mental health disorders like schizophrenia.”

Schizophrenia affects around 1% of the global population and an estimated 635,000 people in the UK will at some stage in their lives be affected by the condition. The projected cost of schizophrenia to society is around £11.8 billion ($18.3 billion US) a year.

The symptoms of schizophrenia can be extremely disruptive, and have a large impact on a person’s ability to carry out everyday tasks, such as going to work, maintaining relationships and caring for themselves or others.

http://www.neuroscientistnews.com/research-news/scientists-identify-schizophrenias-rosetta-stone-gene

My Voice!

All I have is my voice
Don’t try to silence me
I have no mansions
I have no jewels from the bowels of the earth
I have no fame
But I have my voice
I was not allowed one as a child
Awful abuse left me mute
Don’t say anything, she’ll kill you
Not taken seriously, never heard, may as well have sewn my lips together
Now I am grown
And it has taken me a lifetime to find it
But I have my voice
Theatre has shown me I have a voice, even though the words are not mine, the voice is
I will use it to shout about what is important to me in my own words
Mental illness, the insanity in violence and terrorism, the oppression of whole groups of people, the wrongs I perceive in this human society
Don’t tell me to be quiet, don’t tell me to shut up
You can turn away from me, that is your prerogative
But do not silence me
I will not be quiet, I will keep on talking, writing, even singing about issues that are important to me
I am powerful, I have a powerful voice, I will use it to bring attention to wrongs that need to be righted
I have a voice, I have the right!

Theater Gunman’s Family Called Him Mentally Ill, Violent

Another tragedy! UNTREATED mental illness, violent tendencies, easy gun availability.

So what are we calling this? Homeland terrorism or insanity?

Treatment is the key for us, people with mental illness. If our brains and minds are not working properly due to a mental illness, we are not in control of our actions. Treatment is the key, to our living healthy productive lives. Treatment is the key to not allowing tragedies like this, and about scores of other tragedies like this, and all recently, not allowing them to happen. The family of this man tried to get help for him, but the police will not help in prevention, unless a crime has been committed, there is nothing they can do… the doctors won’t help, it is too difficult to help someone who is non compliant. The sick person themselves cannot help because their mind is not working. So what is the answer? The answer is still TREATMENT, medication, and therapy! The Aurora shooter, with his wild eyes, Schizophrenic, the Sandy Hook shooter, with his wild eyes, Schizophrenic and violent, and this man, mentally ill and violent…

Yes, the stigma is there for a reason, people are afraid of mentally ill people for a reason, because they act without reason. The only good thing about mental illness is TREATMENT of it. When a mentally ill person is on medication, in a normal state of mind, then there is no stigma, no possibility of this kind of thing happening.

I thank goodness for Lithium and Seroquel everyday, even if the side effects cause me some discomfort, it is these miraculous compounds that allow me to be normal and functioning. Thank goodness!

http://www.nytimes.com/aponline/2015/07/24/us/ap-us-movie-theater-shooting.html?_r=0

Bipolar Disorder Discovery at the Nano Level

http://www.sciencedirect.com/science/article/pii/S0896627314009088

http://www.yumanewsnow.com/index.php/news/health/8847-bipolar-disorder-discovery-at-the-nano-level

Chicago, Illinois – A nano-sized discovery by Northwestern Medicine® scientists helps explain how bipolar disorder affects the brain and could one day lead to new drug therapies to treat the mental illness.

Scientists used a new super-resolution imaging method – the same method recognized with the 2014 Nobel Prize in chemistry – to peer deep into brain tissue from mice with bipolar-like behaviors. In the synapses (where communication between brain cells occurs), they discovered tiny “nanodomain” structures with concentrated levels of ANK3 – the gene most strongly associated with bipolar disorder risk. ANK3 is coding for the protein ankyrin-G.

“We knew that ankyrin-G played an important role in bipolar disease, but we didn’t know how,” said Northwestern Medicine scientist Peter Penzes, corresponding author of the paper. “Through this imaging method we found the gene formed in nanodomain structures in the synapses, and we determined that these structures control or regulate the behavior of synapses.”

Penzes is a professor in physiology and psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine. The results were published October 22 in the journal Neuron.

High-profile cases, including actress Catherine Zeta-Jones and politician Jesse Jackson, Jr., have brought attention to bipolar disorder. The illness causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. About 3 percent of Americans experience bipolar disorder symptoms, and there is no cure.

Recent large-scale human genetic studies have shown that genes can contribute to disease risk along with stress and other environmental factors. However, how these risk genes affect the brain is not known.

This is the first time any psychiatric risk gene has been analyzed at such a detailed level of resolution. As explained in the paper, Penzes used the Nikon Structured Illumination Super-resolution Microscope to study a mouse model of bipolar disorder. The microscope realizes resolution of up to 115 nanometers. To put that size in perspective, there are 1,000 nanometers in a micron, and there are 25,400 microns in one inch. Very few of these microscopes exist worldwide.

“There is important information about genes and diseases that can only been seen at this level of resolution,” Penzes said. “We provide a neurobiological explanation of the function of the leading risk gene, and this might provide insight into the abnormalities in bipolar disorder.”

The biological framework presented in this paper could be used in human studies of bipolar disorder in the future, with the goal of developing therapeutic approaches to target these genes.

Other authors include Katharine R. Smith, Katherine J. Kopeikina, Jessica M. Fawcett-Patel, Katherine Leaderbrand, Ruoqi Gao, Britta Schurmann, Kristoffer Myczek, Jelena Radulovic and Geoffrey T. Swanson, all of Northwestern University Feinberg School of Medicine.